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To date, our inhibitors have only been tested with p NPG at pH 7.4 17,21

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Escherichia coli, Streptococcus faecalis, Clostridium difficile and certain Salmonella species can bind Se from the body to their own enzymes to use amino acids instead of thiamine-containing amino acids, and can also convert the soluble form of Se to an insoluble form, making it unavailable for absorption by the body (114)

Neither compound has an FDA-approved use, so there is no regulatory efficacy or safety determination to lean on