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Heme oxygenase expression in cardiac tissue Immunohistochemical analysis of cardiac tissue for heme oxygenase-1 showed a considerable increase in the mean % area in the hyperthyroid group compared with all treated groups (Fig

Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]

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