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128 Additionally, thalidomide inhibits M1 macrophage polarization by targeting the transcription factor IRF5, reduces the release of inflammatory signals, significantly reduces the secretion of the proinflammatory cytokines IL-12 and IFN-, and promotes intestinal mucosal healing

Int J Radiat Oncol Biol Phys 71(4):1261-71, 2008

doi: 10.1038/s41586-023-06740-y 264 KuonenFSurbeckISarinKYDontenwillMReggCGillietMet al

However, further studies on the precise localization and interaction of CoQH2-generating mitochondrial enzymes and LDHB are needed to determine their specific contribution to the anti-ferroptotic activity in mitochondria