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6-paradol attenuated necroptosis by hampering TNFR-1/RIPK1/RIPK3/MLKL cascade in Rot-induced PD in rats Relative to the control group, Rot upregulated TNFR-1 mRNA expression by 7-folds along with obvious increase in the protein contents of necroptosis biomarkers RIPk1 by 5.4-folds, RIPK3 by 5.7-folds, and MLKL by 9-folds