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In addition to the three inhibitor types, N -methyl-4-chloropyridine irreversibly inhibits NNMT based on suicide inhibition, where NNMT promotes its methylation and it subsequently reacts with C159 to inhibit NNMT (108)

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Together with folate, cobalamins are essential cofactors required for DNA synthesis in cells where chromosomal replication and division are occurringmost notably the bone marrow and myeloid cells