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Nonenzymatic lactylation is enriched through the glycolysis pathway, which can inhibit enzymatic activity and reduce glycolysis metabolites 102 , while enzyme-regulated lactylation is enriched in inflammatory pathways and can regulate inflammatory homeostasis 16

A human gut bacterial genome and culture collection for improved metagenomic analyses

They are expressed in neurons from the olfactory bulb, cerebral cortex, globus pallidus, lateral septum, cerebellar Purkinje cells, and thalamic nuclei (Crupi et al., 1999

It is generally regarded as safe when used appropriately, though potential side effects may include gastrointestinal discomfort