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However, some individualswhether due to conditions like pernicious anemia, gastrointestinal disorders, or the effects of certain surgeriesmay have trouble absorbing enough B12 from food or oral supplements

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Caffeine and green tea extract produce mild metabolism effects compared to prescription medications

However, although there are studies on the effectiveness of high-dose oral supplementation when symptoms are present, in severe cases of neurological symptoms, B12 should be administered parenterally until the symptoms subside and normal levels are restored