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This process was fundamental in order to buffer ROS flux and a consequent detrimental over increase of self-digestion ( Figure 2 )

Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases

H.IslamK.KenneyJ.NielsenM

In the cytological experiment of exposure to ethanol, it was found that Nrf2 was up-regulated as an adaptive response to CYP2E1-mediated oxidative stress (Seitz et al., 2018)