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Calderon-Larranaga A Journal article: EDUCACIN FSICA Y CIENCIA

Before making the diagnosis of PFIC, in the paediatric population, other cholestasis disorders should always be considered in the differential diagnosis, including biliary atresia, choledochal malformations, congenital endocrine disorders, inborn errors of metabolism (mainly during the neonatal period) as well as autoimmune liver diseases, drug-induced cholestasis and other genetic diseases in older children [72]

In addition, some metabolites and other signalling pathways and receptors are directly or indirectly involved

Thus, the glycolysis pathway would be downregulated and gluconeogenesis would be upregulated