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Data availability The raw data of RNA-sequencing reported in this study has been deposited in the public database of Genome Sequence Archive (GSA) in National Genomics Data Center under the accession number HRA002453, which is accessible at The untargeted metabolomics data was included in an Excel form which is named as untargeted metabolomic data in the Source Data file

Additionally, freshwater GM had a lower alpha diversity than saltwater GM

Wang (Peking University) for helpful discussions and for providing the HT-1080 cells

These fungal species are crucial for maintaining intestinal homeostasis and systemic immunity [12]