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Hyperbaric oxygen therapy for late radiation tissue injury

Nuclear factor E2-related factor 2 (Nrf2) is an essential regulator of oxidative stress, which has attracted extensive attention in the antioxidant mechanism of DN in recent years

doi: 10.1056/NEJMoa1500596

The enzyme is complex, with four copper atoms, two or more disulfides, glycosylation, optimal activity at acidic pH (pH 45) and an electron transfer pathway that is strongly interrupted by modest concentrations of hydroxyl anions or halides (for example, NaCl and KCl) in cell culture media 21