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C ssav = AUC 0t /, is the interval of administration;C ssmin =(C -48h + C -24h + C 0h )/3

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In topical application, studies use concentrations of 0.01-1% in cream or serum formulations (Pickart et al., BioMed Res Int 2015For subcutaneous injection (research), doses vary depending on the experimental model