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In addition, leptin may impair endothelial function through oxidative stress by increasing the formation of ROS that reduce the bioavailability of NO and upregulate proinflammatory cascades including adhesion and chemotactic pathways in endothelial cells [72,73,74]

In clinical trials, fish oil supplementation improves the fatty acid profile in Crohns disease and ulcerative colitis patients, and is associated with lower levels of inflammatory mediators (Uchiyama 2010

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Accelerated solvent extraction has been used to extract phenolics from strawberry and onion peels, with applications focused on evaluating their antimicrobial and antibiofilm activities (75, 76)