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Role of the tight junction in the stomach and related diseases In the stomach, the tight junctions formed by adjacent gastric epithelial cells play a pivotal role in regulating the paracellular permeability of ions, nutrients, and other solutes and preventing digestive enzymes and toxins for entering the systemic circulation

Nevertheless, the evidence base remains limited to moderate in quality, highlighting the need for additional rigorous studies to establish optimal treatment protocols and confirm long-term effectiveness [24]

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The secondary location of breast carcinomas to the lung [28-30] liver [31,32] , lymph nodes [33] , skin [34] and brain [35-37] is frequently due to non-angiogenic growth