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The administration of STZ leads to the DRG becoming more depolarized (m), which in turn causes an increase in mitochondrial ROS, apoptosis, and caspases (caspase-3, caspase-8, and caspase-9) by downregulating enzymatic (glutathione peroxidase, GSH-Px) and non-enzymatic (glutathione (GSH), vitamin A, and vitamin E) antioxidants

73 In a trial comparing lofexidine with diazepam, no differences were seen in OOWS or SOWS on days 3 and 4 (peak withdrawal)

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Targeted Iron Supplementation Iron Sucrose Injection provides a rapid and effective means of correcting iron deficiency anemia, especially in patients with chronic kidney disease