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have confirmed that the increase of circulating TMAO downregulates IL-10 and promotes vascular inflammation, contributing to endothelial dysfunction by mouse experiments (55)

A change in the regulation of Ca 2+ in lymphocytes disrupts the control of metabolism, proliferation, differentiation, secretion of antibodies, cytokines and cytotoxicity, which leads to autoimmune and inflammation diseases (130)

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Previous studies have shown hypoperfusion and reduction in the biosynthesis of neurotransmitters such as gamma aminobutyric acid (GABA), glutamate, and aspartate in the frontal, occipital, cingulate, and temporal cortices and basal ganglia