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Under normal conditions in senescent cells, FOXO4 interacts with p53 and retains it in the nucleus, preventing p53 from translocating to mitochondria and executing its intrinsic pro-apoptotic programme

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For this reason, its important to use gentle, hydrating skincare products throughout isotretinoin treatment

le (R)-2-[[[(1-phnylthyl)amino]carbonyl]amino]-N-(2-chloro-6-mthylphnyl)-6-benzothiazole carboxamide