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Canonical Hedgehog pathway and noncanonical GLI transcription factor activation in cancer

A thorough research analysis revealed that the Western diet exacerbated PD progression due to the poor quality of fiber, whereas the Mediterranean diet, high in fiber and polyphenols alleviated the symptoms of PD (142)

In the pathological process of OA, cartilage degeneration is a key event

Pro-inflammatory cytokines stimulate corticotropin-releasing hormone (CRH) secretion and impair glucocorticoid receptor signaling, resulting in diminished negative feedback and sustained hypercortisolemia