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The pivotal trials enrolled hundreds of subjects and used CT-measured visceral adipose tissue (VAT) as the primary endpoint, a harder measure than BMI or waist circumference

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In brain regions other than the hypothalamus, ghrelin receptor expression was detected in the CA2 and CA3 regions of the hippocampus, substantia nigra, ventral tegmental area, dorsal raphe nucleus, and median raphe nucleus, indicating its potential role in learning and memory (Guan et al., 1997