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Acknowledgments This study was approved by the ethics committee of Shengjing Hospital of China Medical University (No.2016PS43K) and the Animal Ethics Committee of China Medical University

J Biol Chem 258:984989 Holmgren A (1976) Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate reductase dependent upon glutathione

This process is accompanied by the ETC breakdown with the failure to produce the necessary amount of ATP, uncompensated production of ROS and RNS, and breakdown of various molecules, which leads to the loss of mitochondrial and cell integrity, and activation of programmed cell death and necrosis

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