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2 Endocrine / GHRH pharmacologyModified GRF 1-29 (CJC-1295) as a short-acting GHRH analog and its pulsatile GH effect

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The lead candidate 37 (HFI-419) exhibits brain exposure following intravenous administration in rats but was found to be rapidly degraded to the corresponding deacetylated and less active IRAP inhibitor (Mountford et al., 2014)