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April 5 Product: Johnson & Johnson and Legend Biotechs Carvykti Indication: Multiple myeloma Johnson & Johnson and Legend Biotechs Carvykti is now approved for the second-line treatment of multiple myeloma

In the investigator-initiated trial, two drug-related adverse events occurred in the experimental groupspecifically, toothache and injection site swellingwhile one participant in the control group experienced an injection-related adverse event (injection site swelling)

298 Notably, mitochondrial copper can directly bind to proteins following their lipoylation, a post-translational modification involving the covalent attachment of an eight-carbon organosulfur lipoic acid moiety to specific lysine residues, leading to the aggregation of lipoylated proteins