l-carnitine study Supplementation in Recovery after Exercise Efficacy of L-carnitine supplementation on

doi: 10.1194/jlr.R400013-JLR200 48 GlomsetJ

Larger animals better match human anatomy (e.g., nerve size, BSCB/BBB integrity), immunological responses, and pharmacokinetics, hence overcoming the limitations of rodent-scale biodistribution and dosage [183, 184]

Second, multiple administrations can trigger the formation of circulating anti-PEG antibodies, which can thus hinder the actual utility of this polymer in the first place and prime hypersensitivity reactions, which are a great concern for NP safety (Gref et al., The first limitation may be overcome by a careful optimization of PEG features such as length, coating density, and overall structure, which must be considered in order to maximize its benefits

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