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It has been shown only the R-form is used by mitochondrial alpha-keto acid dehydrogenases

Sheoran R, Khokra SL, Chawla V, Dureja H

Introduction Cognitive enhancement may be defined as the amplification or extension of core capacities of the mind through improvement or augmentation of internal or external information processing systems ( via physical, behavioral and biochemical activities ( Cognitive enhancer drugs (CEs) are also known as nootropics (from the Greek nous meaning mind and trepein meaning turning/bending), a term initially penned by Corneliu Giurgea when piracetam was found to exhibit memory-enhancing properties in clinical trials ( Cognitive Enhancers, Historical Perspective and State of the Art Historically, CEs have been used to treat conditions related to cognition deficits such as Alzheimers disease, psychiatric disorders such as schizophrenia ( The world of CEs is multifaceted and complex, with different molecules acting with different modes of actions and on different (and often multiple) receptors in the central nervous system (CNS)