Secondly, within this continuum, it is difficult to predict which patients are at risk of deteriorating
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List of Abbreviations ACL anterior cruciate ligament AGE advanced glycation end product AP-1 activating protein-1 BAPN -aminopropionitrile BMP-1 bone morphogenetic protein-1 Col1a1 collagen type I alpha 1 chain Col3a1 collagen type III alpha 1 chain CRL cytokine receptor-like CSA cross-sectional area CypB cyclophilin B DOGDIC 3-deoxyglucosone-derived imidazolium ECM extracellular matrix ER endoplasmic reticulum GODIC glyoxal-derived imidazolium HH Hamburger-Hamilton HIF hypoxia inducible factor HP hydroxylysyl pyridinoline hPDL human periodontal ligament HPLC high-performance liquid chromatography Hyl hydroxylysine JNK c-Jun N-terminal kinases LH lysyl hydroxylase LOX lysyl oxidase LOXL LOX-like protein LOX-PP LOX pro-peptide LP lysyl pyridinoline LTQ lysyltyrosine quinone MAPK mitogen-activated protein kinase MCL medial collateral ligament MCP 2-mercaptopyridine-N-oxide MGO metabolite methylglyoxal MMP matrix metalloproteinase MODIC methylglyoxal-derived imidazolium P3H prolyl-3-hydroxylase P4HA prolyl 4-hydroxylase subunit alpha PCP procollagen-C-proteinase PDI protein disulfide isomerase PDL periodontal ligament PIEZO1 Piezo type mechanosensitive ion channel component 1 PLOD procollagen lysyl hydroxylase Pyr pyridinoline RT-PCR reverse transcription polymerase chain reaction SAXS small-angle X-ray scattering SDFT superficial digital flexor tendon SDS-PAGE sodium dodecyl sulfatepolyacrylamide gel electrophoresis SEM scanning electron microscopy SLRP small leucine-rich proteoglycan SNAIL snail SOX9 SRY-box transcription factor 9 TCP trans-2-phenylcylopropylamine TEM transmission electron microscopy TG transglutaminase TGF transforming growth factor beta TGFR TGF receptor Thbs1 thrombospondin-1 gene TIMP tissue inhibitor of MMP TSP-1 thrombospondin-1 References Ahmed AS, Schizas NL,J, Ahmed M, Ostenson C-G, Salo P, Hewitt C, Hart DA, Ackermann PW (2012) Type 2 diabetes impairs tendon repair after injury in a rat model
All models included participants' gender, ages, mothers' ages, fathers' ages, and races as covariates
