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References: Babu MM, Luscombe NM, Aravind L, Gerstein M, Teichmann SA

NAFLD is defined by exclusion, emphasizing that the disease is not caused by alcohol consumption, but this definition is overly broad and fails to accurately reflect the metabolic drivers of the disease

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and (ii) delivery-related issues, as PLGA nanoparticles require further engineering to achieve high selectivity and specificity, overcome BBB restrictions, and effectively target pathological sites, and/or multi-targeting strategies may be necessary as AD exhibits multiple pathological targets (Lu et al., 2023)