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Inspired by the structure of guava fruit, the team co-loaded free RVT and RVT particles within the MN, constructing the guava-like valves and chambers, which act as an active engine to promote drug permeation by generating capillary forces

Their implication in CIPN through the overload of Ca 2+ entry has been demonstrated (Hill and Oliver, PKC enzyme: Apart from the involvement of PKC on the induction of oxidative stress in neurons, both human and animal studies have linked this enzyme to several pain types through excessive Ca 2+ entry and cation channel activation (Carozzi et al., 2009)

J., Cohn, D