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Although our measurements were not region-specific, high-dose paraxanthine augmented BDNF levels more than caffeine, suggesting a dose-dependent effect of paraxanthine, regardless of age

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Table S6: Predicted subcellular localization of *RsGST* proteins in *Rhododendron simsii* based on CELLO v2.5;Table S7: Conserved domain architecture of the identified *RsGST* proteins in *Rhododendron simsii* ;Table S8: unanchored RsGST scaffoldIDs