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Symptoms of Feline Respiratory Disease Complex in Cats When cats get sick with respiratory disease complex, their main symptoms are respiratory, although other body symptoms can be affected: Symptoms of feline herpesviral rhinotracheitis: Nasal congestion Sneezing Conjunctivitis Eye and nasal discharge (soon becomes full of mucus and pus) Excess salivation Intermittent fever Anorexia Depression Enlarged lymph nodes Squinting of the eyes (blepharospasm) Difficult time breathing Symptoms of feline calicivirus: Limping syndrome (lameness in the legs with pain on handling) Fluid build up in the lungs Pneumonia Gum and mouth inflammation Fever Low appetite Depression Nasal inflammation Conjunctivitis Cats infected with both illnesses at the same time may develop mouth ulcers, making eating and drinking water painful

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But the jump from C57BL/6 mice to humans involves differences in metabolic rate, NNMT tissue distribution, adipose tissue physiology, and drug metabolism that preclinical data cannot address