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8.6 Patients with Hepatic Impairment No dose adjustment for mild to moderate impairment is required

Ultimately, this review aims to integrate fragmented research findings, reveal potential common patterns underlying processing-induced detoxification, and propose an integrated research strategy combining physical detoxification chemical transformation of toxic constituents modulation of in vivo processes, thereby providing a theoretical basis for a deeper understanding of the scientific principles underlying processing-induced detoxification and for guiding the optimization and innovation of processing technologies

The transforming growth factor- (TGF-)/Smad signaling pathway is a major pathway in renal fibrosis, and it is closely related to ferroptosis (190)

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