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A previous study revealed that BER protected against neuronal cell death by inducing the antioxidant HO-1 [103]

Bethanechol chloride does not cross the blood-brain barrier because of its charged quaternary amine moiety

Int J Mol Sci 2015

The early-stage patient fibroblasts showed a significantly higher basal respiration than TDP-43 G376D Asymptomatic fibroblasts, but a much lower spare respiratory capacity, whereas late-stage patient fibroblasts behaved as the TDP-43 G376D Asymptomatic fibroblasts, having similar basal respiration, maximal respiration, and spare respiratory capacity (Fig