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CMAJ 2011

In addition, NOR also inhibited the reduction of AhR/NF-B/p65 complex caused by nuclear translocation of NF-B p65 in osteoclasts, and reduced the expression of VEGF, resulting in the reduction of accumulation of ARNT/HIF-1 complex, suggesting that NOR reduced osteoclast differentiation and bone erosion by activating AhR and inhibiting the subsequent NF-B and HIF pathways (81)

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This led the authors to hypothesize that the synaptic and astrocytic dysfunction could be mechanistically linked and that the tripartite synapse could be pivotal in switching the pathogenesis toward ALS (Broadhead et al., 2022)