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For all of the participants with focal dystonia, it had been at least 3 months since their last botulinum toxin injection and they were symptomatic during the performance of their dystonia-related tasks

Challenges and Gaps in Research While estrogen-based therapies, such as HRT and SERMs, have demonstrated significant benefits in managing menopausal mental health issues, their use is not without significant challenges and controversies

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A double-blind randomized placebo-controlled trial found that amifostine (740 mg/m 2 ) improved the sensory neuropathy induced by platinum/taxane-based treatment of ovarian cancer, but there was almost no difference in specific sensory or motor symptoms of self-estimation [150]