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However, ROS alters actin polymerization and stability, which disrupts epithelial cell barrier functions

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FEBS Lett 563:185190 Gao Y, Hannan NR, Wanyonyi S, Konstantopolous N, Pagnon J, Feng HC, Jowett JB, Kim KH, Walder K, Collier GR (2006) Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells

Preclinical studies have not identified toxic doses or lethal doses for BPC-157, and researchers reported no teratogenic, genotoxic, anaphylactic, or local toxic effects