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Embodiment 168 The formulation according to any one of embodiments said formulation is formulated for administration via a route selected from the group consisting of oral administration, nasal administration, rectal administration, intraperitoneal injection, intravascular injection, subcutaneous injection, transcutaneous administration, and intramuscular injection

Vitamin C acts as a necessary cofactor for the enzymes prolyl hydroxylase and lysyl hydroxylase

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The alteration of NAD + metabolism in sPD cells contributes to the activation of SIRT2 and subsequently reduces the acetylation level of -tubulin