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Abbreviations PD: Parkinsons disease DA: Dopaminergic SNc: Substantia nigra pars compacta LBs: Lewy bodies Syn: Synuclein (Protein) LBP: Lewy body pathology CNS: Central nervous system iLBD: Incidental Lewy body disease DMV: Dorsal motor nucleus of the vagus nerve AD: Alzheimers disease LRRK2: Leucine - rich repeat kinase 2 PARK2: Parkinson juvenile disease protein 2 STED: Stimulated emission depletion PINK1: PTEN-induced kinase 1 cPD: Clinical PD pPD: Prodromal PD TH: Tyrosine Hydroxylase SNARE: Soluble N-ethylmaleimide-sensitive-factor attachment receptor SNAP29: Synaptosome Associated Protein 29 TLR-2: Toll-like-Rezeptor 2 Cd68: Cluster of Differentiation ACC: Anterior cingulate cortex PAR2: Protease activated receptor 2 MCM2: Minichromosome maintenance protein 2 HC: Hippocampus LC: Locus caeruleus VMAT2: Vesicular monoamine transporter 2 DJ-1: Protein deglycase 1 Rab38B: Ras-related in brain mTOR: Mammalian Target of Rapamycin eIF2: Elongation initiation factor mtDNA: Mitochondrial DNA GAPDH: Glyceraldehyde dehydrogenase GSH: Glutathion FMRP: Fragile X mental retardation protein RBD: REM sleep behaviour disorder iRBD: Idiopathic RBD DaT: Dopamine Transporter PET: Positron emission tomography TSPO: 18 KDa translocator protein (pre-)LBD: (Pre-)Lewy body disease sNfL: Serum neurofilament light chain DaT: Dopamine Transporter GBA: Glucocerebrosidase SNCA: Alpha-Synculein (Gene) References Berg D, Postuma RB, Bloem B, Chan P, Dubois B, Gasser T, et al

(b) CT scan after iodinated contrast injection, proximal to the left ankle joint, confirmed the mass lesion in the subcutaneous fat next to the extensor digitorum longus muscle

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