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Sensory information from the abdominal organs traverses the vagus nerve to the nucleus of the solitary tract in the brainstem, with projections to several other areas of the CNS, including the cerebral cortex and medulla oblongata (Liu and Forsythe, 2021)

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Manifestations of hypothyroidism on the hematopoietic system include a normocytic anemia due to reduced renal erythropoietin synthesis, microcytic anemia due to defects in iron absorption, or megaloblastic anemia due to associated autoimmune gastritis leading to vitamin B 12 deficiency