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Mitochondria as the Primary Source of ROS in Neurons Electron Transport Chain (ETC) Leakage: During oxidative phosphorylation, electrons can leak from the ETC complexes (especially Complexes I and III) and react with molecular oxygen to form superoxide anions (O), a primary ROS

Promisingly, some of the technical difficulties in measuring the heterocomplex, due to the inherent instability of the cluster, have begun to be addressed in the last year [123] opening new opportunities to better understand the role of Grx5 in iron trafficking