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Chemical peel treatment can make the skin appear red and the patch can stay for a month or a couple of months discoloration of the skin may be possible as the skin can become darker or lighter [233]

FIGURE 5 One of the best-known representatives of SOD mimetics is the drug 4-Hydroxy-TEMPO (TEMPOL), which had shown effectiveness in a number of preclinical and clinical studies of the treatment of autoimmune, cardiovascular diseases, and oncological diseases (Kim et al., 2016)

This benefit perhaps reflects the capacity of residual enzyme activity to be enhanced by the presence of the cofactor