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Miki Shigefuji and Yoshihiro Tokudome reported that formulating hydrophilic HA into nanoparticles could reduce their interaction with keratin and transform their transdermal mode from a transcellular route to an intercellular route [31]

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10.1016/j.bjorl.2019.01.003 Braz

Another study showed that administering NRD at doses of 100 and 200 mg/kg for 21 days prevented ISO-induced elevation of cardiac and liver marker enzymes ( 6.1.5 Salvianolate Salvianolate (Sal), a water-soluble component primarily composed of 80% magnesium B acetate, is derived from the Chinese medicine Danshen and is widely used to treat cardiovascular diseases (Qi et al., 2018)