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10.1016/j.biomaterials.2021.121071 73 XieJ.GongL.ZhuS.YongY.GuZ.ZhaoY

In neuroprotection, the combination reduces oxidative stress markers by 45% in neuronal cell cultures

NADPH is a critical reductant produced during immune metabolism, maintaining the function of intracellular antioxidant systems (e.g., thioredoxin and glutathione systems) and bidirectionally regulating ROS production and clearance in certain cells such as macrophages 143,144,145,146