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Why this matters: Tirzepatide alone already very powerful (15-22%) May already be optimizing GIP/GLP-1 pathways maximally Adding amylin might only add 2-5% more weight loss But could significantly increase side effects Risk-benefit ratio unknown Contrast with CagriSema: CagriSema: Extensively studied, Phase 3 trials, known safety Tirzepatide + cagrilintide: Zero studies, no safety data, speculative Learn about evidence-based approaches at SeekPeptides - explore best peptides for weight loss and best peptide stack for weight loss

doi: 10.1186/s13045-019-0720-y 12 MaLChenCZhaoCLiTMaLJiangJet al

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Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver