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Mol Med Rep 2017, 15 (1), 387395

Fetal/Neonatal Adverse Reactions Oligohydramnios in pregnant women who use drugs affecting the renin-angiotensin system in the second and third trimesters of pregnancy can result in the following: reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension and death

As discussed earlier, these variants significantly increased blood acetaldehyde concentrations after alcohol consumption, leading to heightened aversive effects and reduced risk for AUD

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