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Of the six studies that measured co-factors of the -glutamyl cycle or trans-sulphuration pathway, five studies showed elevated levels of vitamin B6 in children with autistic disorder or autism spectrum disorders compared to controls [73, 76, 87, 92, 93], one showed a decrease in erythrocyte selenium in children with autistic disorder [78] and another showed no change in whole blood selenium in children with an autism spectrum disorder compared to controls [87]

The authors found increased phosphorylation of Drp-1 in human retinal microvascular endothelial cells (RMECs) subjected to high glucose (33 mM) treatment for 3 days (Zhang et al., 2022)

doi: 10.31083/j.jin2102073

The study therefore demonstrates the pro-engiogenic effects of BPC 157 associated with VEGFR2 and VEGFR2-Akt-eNOS signalling