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The ephrin pathway plays a crucial role in immune function and inflammatory responses and proteomics studies further support evidence of chronic inflammation, perhaps chronic infection (Milivojevic et al., 2020) and immune dysregulation (Giloteaux et al., 2023), with additional links to coagulation abnormalities and chronic infection (Nunes et al., 2022)

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Although PPV was considered an attractive strategy for PCa, and even after successful phase II trials, the phase III trial of 310 patients with mCRPC receiving docetaxel found no survival advantage over PBO (HR 1.04