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[] Thus, cardiolipin binding and GTP hydrolysis represent fundamental prerequisites, although the detailed mechanisms underlying these processes remain unclear

not trial-validated Endpoint Skin density (instrument-measured) Topical timeline 12 weeks Injectable framing Anecdotal

When to increase dose Consider increasing if: Minimal response after 4-6 weeks at current dose No side effects at current dose Current dose below the higher end of recommended range Goals not being met with conservative approach Increase gradually, typically by 25-50% at a time

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