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Description

Once tumor cells reach distant metastatic sites, ZFP281 maintains tumor dormancy and prevents tumor proliferation over extended periods via the induction of the class IIcadherin 11

This mechanism is relevant in SLE, where there is excessive NETosis that acts to promote injury and disease development (93)

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J Leukoc Biol 52:135142 Blomberg OS, Spagnuolo L, Garner H, Voorwerk L, Isaeva OI, van Dyk E, Bakker N, Chalabi M, Klaver C, Duijst M et al (2023) IL-5-producing CD4(+) T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer