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The NTA ligand coordinates the Ni2+ with four valencies (tetradentate, coordination number 4), and two valencies are available for interaction with imidazole rings of histidine residues

52 Overall, GTP is suggested as a safer alternative for patients with KOA, particularly those with cardiovascular and gastrointestinal comorbidities, due to its lower incidence of gastrointestinal adverse events compared to NSAIDs

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This ensures the treatment is appropriate for your specific health goals and medical history