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Description

The common inflammatory indicator MMP-12 exhibits elevated expression levels as individuals age, whereas AD patients skin shows the opposite trend

The recent discovery of pharmacological ABHD5 ligands that disrupt the interaction between ABHD5 and PLIN1 (48) demonstrate that the dissociation of ABHD5 is sufficient to stimulate adipocyte lipolysis and that these protein interactions can be targeted pharmacologically (34, 48, 49)