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Its primary effects are mediated through three transcription factors from the GLI family, which includes GLI1, GLI2, and GLI3 (Omenetti et al., 2011

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BH4 not only takes part in numerous central metabolic processes by serving as an important cofactor for various enzymes (96), but also downregulates the oxidative degradation of phospholipids contained two PUFA tails by serving as a direct antioxidant and an important regulator in CoQ 10 synthesis (94), thus inhibiting lipid peroxidation and inducing ferroptosis

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miR-142-3p impairs the expansion and function of nTregs by downregulating the autophagy-related protein ATG16L1 at both the mRNA and protein levels [82]

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